Gene name:
SLC27A5 (ACSB;ACSVL6;FACVL3;FATP5) ;
Protein name:
Bile acyl-CoA synthetase (BACS) ;
Alternative:
Cholate--CoA ligase ;Bile acid-CoA ligase (BA-CoA ligase;BAL) ;Fatty-acid-coenzyme A ligase, very long-chain 3 ;Fatty acid transport protein 5 (FATP-5) ;Very long-chain acyl-CoA synthetase homolog 2 (VLCS-H2;VLCSH2) ;Solute carrier family 27 member 5 ;Very long-chain acyl-CoA synthetase-related protein (VLACS-related;VLACSR) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGVRQQLALL | LLLLLLLWGL | GQPVWPVAVA | LTLRWLLGDP | TCCVLLGLAM |
100:
LARPWLGPWV | PHGLSLAAAA | LALTLLPARL | PPGLRWLPAD | VIFLAKILHL |
150:
GLKIRGCLSR | QPPDTFVDAF | ERRARAQPGR | ALLVWTGPGA | GSVTFGELDA |
200:
RACQAAWALK | AELGDPASLC | AGEPTALLVL | ASQAVPALCM | WLGLAKLGCP |
250:
TAWINPHGRG | MPLAHSVLSS | GARVLVVDPD | LRESLEEILP | KLQAENIRCF |
300:
YLSHTSPTPG | VGALGAALDA | APSHPVPADL | RAGITWRSPA | LFIYTSGTTG |
350:
LPKPAILTHE | RVLQMSKMLS | LSGATADDVV | YTVLPLYHVM | GLVVGILGCL |
400:
DLGATCVLAP | KFSTSCFWDD | CRQHGVTVIL | YVGELLRYLC | NIPQQPEDRT |
450:
HTVRLAMGNG | LRADVWETFQ | QRFGPIRIWE | VYGSTEGNMG | LVNYVGRCGA |
500:
LGKMSCLLRM | LSPFELVQFD | MEAAEPVRDN | QGFCIPVGLG | EPGLLLTKVV |
550:
SQQPFVGYRG | PRELSERKLV | RNVRQSGDVY | YNTGDVLAMD | REGFLYFRDR |
600:
LGDTFRWKGE | NVSTHEVEGV | LSQVDFLQQV | NVYGVCVPGC | EGKVGMAAVQ |
650:
LAPGQTFDGE | KLYQHVRAWL | PAYATPHFIR | IQDAMEVTST | FKLMKTRLVR |
690:
EGFNVGIVVD | PLFVLDNRAQ | SFRPLTAEMY | QAVCEGTWRL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Polyclonal Antibody for Human BACS
Polyclonal Antibody for Human BACS
Polyclonal Antibody for Human BACS
Monoclonal Antibody for Human BACS
Monoclonal Antibody for Human BACS
Monoclonal Antibody for Human BACS
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;TOPOLOGY