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Index > Protein center > SLC27A5(Gene name) > Human
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  • SLC27A5 (Gene name),
  • Bile acyl-CoA synthetase (Protein name ),  S27A5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SLC27A5(ACSB;ACSVL6;FACVL3;FATP5);
    Protein name:
    Bile acyl-CoA synthetase(BACS);
    Alternative:
    Cholate--CoA ligase;Bile acid-CoA ligase(BA-CoA ligase;BAL);Fatty-acid-coenzyme A ligase, very long-chain 3;Fatty acid transport protein 5(FATP-5);Very long-chain acyl-CoA synthetase homolog 2(VLCS-H2;VLCSH2);Solute carrier family 27 member 5;Very long-chain acyl-CoA synthetase-related protein(VLACS-related;VLACSR);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    690
    Sequence:
    50:
    MGVRQQLALL | LLLLLLLWGL | GQPVWPVAVA | LTLRWLLGDP | TCCVLLGLAM | 
    100:
    LARPWLGPWV | PHGLSLAAAA | LALTLLPARL | PPGLRWLPAD | VIFLAKILHL | 
    150:
    GLKIRGCLSR | QPPDTFVDAF | ERRARAQPGR | ALLVWTGPGA | GSVTFGELDA | 
    200:
    RACQAAWALK | AELGDPASLC | AGEPTALLVL | ASQAVPALCM | WLGLAKLGCP | 
    250:
    TAWINPHGRG | MPLAHSVLSS | GARVLVVDPD | LRESLEEILP | KLQAENIRCF | 
    300:
    YLSHTSPTPG | VGALGAALDA | APSHPVPADL | RAGITWRSPA | LFIYTSGTTG | 
    350:
    LPKPAILTHE | RVLQMSKMLS | LSGATADDVV | YTVLPLYHVM | GLVVGILGCL | 
    400:
    DLGATCVLAP | KFSTSCFWDD | CRQHGVTVIL | YVGELLRYLC | NIPQQPEDRT | 
    450:
    HTVRLAMGNG | LRADVWETFQ | QRFGPIRIWE | VYGSTEGNMG | LVNYVGRCGA | 
    500:
    LGKMSCLLRM | LSPFELVQFD | MEAAEPVRDN | QGFCIPVGLG | EPGLLLTKVV | 
    550:
    SQQPFVGYRG | PRELSERKLV | RNVRQSGDVY | YNTGDVLAMD | REGFLYFRDR | 
    600:
    LGDTFRWKGE | NVSTHEVEGV | LSQVDFLQQV | NVYGVCVPGC | EGKVGMAAVQ | 
    650:
    LAPGQTFDGE | KLYQHVRAWL | PAYATPHFIR | IQDAMEVTST | FKLMKTRLVR | 
    690:
    EGFNVGIVVD | PLFVLDNRAQ | SFRPLTAEMY | QAVCEGTWRL | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human BACS
    Cat.:
    E9332h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human BACS
    Cat.:
    E9332m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human BACS
    Cat.:
    E9332r
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    MSDS:
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    96T
    Range:
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    CLIA Kit for Human BACS
    Cat.:
    U9332r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human BACS
    Cat.:
    U9332m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human BACS
    Cat.:
    U9332h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human BACS
    Cat.:
    P9332Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human BACS
    Cat.:
    P9332Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human BACS
    Cat.:
    P9332Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human BACS
    Monoclonal Antibody for Human BACS
    Monoclonal Antibody for Human BACS
    Protein for Human BACS
    Protein for Human BACS
    Protein for Human BACS

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    References
    1. 1.
      "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein."
      Steinberg S.J. , Wang S.J. , McGuinness M.C. , Watkins P.A.
      Mol. Genet. Metab.68:32-42(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Liver.
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase."
      Steinberg S.J. , Mihalik S.J. , Kim D.G. , Cuebas D.A. , Watkins P.A.
      J. Biol. Chem.275:15605-15608(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
    6. 6.
      "Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling."
      Mihalik S.J. , Steinberg S.J. , Pei Z. , Park J. , Kim do G. , Heinzer A.K. , Dacremont G. , Wanders R.J. , Cuebas D.A. , Smith K.D. , Watkins P.A.
      J. Biol. Chem.277:24771-24779(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;TOPOLOGY
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